cytohesin-4; PH, SEC7 & coiled-coil domain-containing protein 4; ARF nucleotide binding site opener-4; ARNO-4 (CYTH4 CYT4 PSCD4)

Function

• promotes guanine-nucleotide exchange on ARF1 & ARF5
• promotes activation of ARF through replacement of GDP with GTP

Structure

• contains 1 PH domain
• contains 1 SEC7 domain

Expression

• expressed predominantly in peripheral blood leukocytes

More general terms

• cytohesin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=27128
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:27128
• OMIM: https://mirror.omim.org/entry/606514
• UniProt: http://www.uniprot.org/uniprot/Q9UIA0.html