RAS guanyl-releasing protein 4 (RASGRP4)

Function

• cation- & diacylglycerol (DAG)-regulated guanine nucleotide exchange factor activating Ras through exchange of bound GDP for GTP
• may function in mast cells differentiation

Structure

• phorbol-ester/DAG-type Zn+2 finger mediates the binding & the functional activation by DAG
• belongs to the RASGRP family
• contains 1 EF-hand domain
• contains 1 N-terminal Ras-GEF domain
• contains 1 phorbol-ester/DAG-type Zn+2 finger
• contains 1 Ras-GEF domain

Compartment

• cytoplasm, cell membrane
• recruited to membranes upon activation by DAG

Alternative splicing

named isoforms=4

Expression

• expressed by mast cells & their progenitors (at protein level)
• specifically expressed in mononuclear leukocytes
• highly expressed in myeloid cells compared to lymphoid cells
• detected in heart, skeletal muscle, spleen, liver, placenta & lung
• not detected in brain
• expressed early during development
• detected in all fetal tissues tested

More general terms

• zinc finger protein
• Ca+2 binding protein
• guanine nucleotide exchange factor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1157
• OMIM: https://mirror.omim.org/entry/607320
• UniProt: http://www.uniprot.org/uniprot/Q8TDF6.html