synembryn-B (brain synembrin, hSyn, protein Ric-8B)

Function

• guanine nucleotide exchange factor (GEF)
• can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP
• able to potentiate Golf-alpha-dependent cAMP accumulation
• odorant signal transduction (putative)
• interacts with GDP-bound G alpha proteins GNAI1, GNAL, GNAS & GNAQ
• does not interact with G-alpha proteins when they are in complex with subunits G-beta & G-gamma

Structure

belongs to the synembryn family

Compartment

• cytoplasm, cell cortex
• localizes to cell cortex

Alternative splicing

named isoforms=4

More general terms

• guanine nucleotide exchange factor

Database

• UniProt: http://www.uniprot.org/uniprot/Q9NVN3.html