gsp proto-oncogene (GNAS1)
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Pathology
- defects in GNAS/GNAS1 are the cause of GNAS hyperfunction GNAS locus is imprinted in a complex manner, giving rise to distinct paternally, maternally & biallelically expressed proteins. - XLas isoforms are paternally derived - Gnas isoforms are biallelically derived - Nesp55 isoforms are maternally derived
More general terms
References
- ↑ Hunter T. Cooperation between oncogenes. Cell. 1991 Jan 25;64(2):249-70. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1988147 ALEX & XLas are derived from an overlapping reading frame