extra large alpha-s protein (guanine nucleotide-binding protein Gs subunit alpha isoforms XLas, adenylate cyclase-stimulating G alpha protein, XLalphas, GNAS, GNAS1)

Function

• XLas isoforms interact with same set of receptors as Gnas isoforms
• interacts through its N-terminal region with ALEX*
  • interaction may inhibit its adenylyl cyclase-stimulating activity

Compartment

peripheral membrane

Alternative splicing

named isoforms=6

* protein is produced by a bicistronic gene which also produces ALEX protein from an overlapping reading frame XLas isoforms are paternally derived

More general terms

• Gs-alpha

Database

• OMIM: https://mirror.omim.org/entry/139320
• UniProt: http://www.uniprot.org/uniprot/Q5JWF2.html