protein ALEX (Alternative gene product encoded by XL-exon, guanine nucleotide-binding protein alpha-stimulating activity polypeptide 1, secretogranin 6, neuroendocrine secretory protein 55, nesp55, GNAS, GNAS1)

Function

• may inhibit the adenylyl cyclase-stimulating activity of guanine nucleotide-binding protein Gs alpha, produced from the same locus in a different open reading frame
• interacts with the N-terminal region of the XLas isoforms of guanine nucleotide-binding protein Gs alpha

Compartment

• cell membrane, peripheral membrane protein
• predominantly associated with cell membrane ruffles

Pathology

• defects in GNAS/GNAS1 are the cause of GNAS hyperfunction

Genetics

• protein is produced by a bicistronic gene which also produces Gs alpha from an overlapping reading frame, also NESP55 ??

More general terms

• membrane protein

Additional terms

• neuroendocrine secretory protein 55 (NESP55, guanine nucleotide-binding protein, alpha-stimulating activity polypeptide 1, secretogranin 6, GNAS, GNAS1)

Database

• OMIM: https://mirror.omim.org/entry/139320
• UniProt: http://www.uniprot.org/uniprot/P84996.html