guanine nucleotide exchange factor GEFT; RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT, Rac/Cdc42/Rho exchange factor GEFT; p63RhoGEF (GEFT, ARHGEF25)

Function

• may play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers
• works as a guanine nucleotide exchange factor for Rho family of small GTPases
• links specifically G alpha q/11-coupled receptors to RHOA activation
• may be an important regulator of processes involved in axon & dendrite formation.
• in neurons seems to be an exchange factor primarily for RAC1
• involved in skeletal myogenesis (putative)
• interacts with activated GNAQ & GNA11
• interacts with RHOA, CDC42 & RAC1

Structure

• guanine nucleotide exchange activity is autoinhibited by the PH domain
• contains 1 DH (DBL-homology) domain
• contains 1 PH domain

Compartment

• cytoplasm, myofibril, sarcomer
• highly colocalizes with actin regions

Alternative splicing

named isoforms=2

Expression

• isoforms 1 & 2 are highly expressed in excitable tissues, such as brain, heart & muscle
• detected in kidney & liver

More general terms

• guanine nucleotide exchange factor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1155
• UniProt: http://www.uniprot.org/uniprot/Q86VW2.html