Rho guanine nucleotide exchange factor 10-like protein (grinchGEF, ARHGEF10L, GRINCHGEF, KIAA1626)

Function

• acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB & RHOC
• interacts with RHOA, RHOB & RHOC

Structure

contains 1 DH (DBL-homology) domain

Compartment

cytoplasm

Alternative splicing

named isoforms=5

Expression

• detected in heart, liver, skeletal muscle, kidney & pancreas

More general terms

• guanine nucleotide exchange factor
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9HCE6.html