protein RCC2 (telophase disk protein of 60 kD, RCC1-like protein TD-60, RCC2, KIAA1470, TD60)

Function

• completion of mitosis & cytokinesis
• guanine nucleotide exchange factor for small GTPase RAC1
• binds preferentially to the nucleotide-free form of RAC1
• interacts with microtubules

Structure

• contains 7 RCC1 repeats

Compartment

• nucleus, nucleolus
• appears in the nucleus at G2, then concentrates at the inner centromere region of chromosomes during prophase
• redistributes to the midzone of the mitotic spindle during anaphase

More general terms

• guanine nucleotide exchange factor

Database

• UniProt: http://www.uniprot.org/uniprot/Q9P258.html