IQ motif & Sec7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100, ADP-ribosylation factors guanine nucleotide-exchange protein 2, brefeldin-resistant Arf-GEF 2 protein, IQSEC1, ARFGEP100, BRAG2, KIAA0763)

Function

• accelerates GTP gamma S binding by ARFs of all 3 classes
• guanine nucleotide exchange factor for ARF6
• mediates internalization of beta-1 integrin

Structure

• belongs to the BRAG family
• contains 1 IQ domain
• contains 1 PH domain
• contains 1 SEC7 domain

Compartment

• cytoplasm, nucleus
• at steady state, may be preferentially cytosolic

Alternative splicing

named isoforms=2

Expression

• expressed in brain, ovary, heart, lung, liver, kidney, leukocytes > lung, skeletal muscle, placenta, small intestine, pancreas, spleen, testis

More general terms

• guanine nucleotide exchange factor
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q6DN90.html