Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2, PDZ-GEF2, RA-GEF-2, RAPGEF6, PDZGEF2)

Function

• guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A & M-Ras GTPases
• does not interact with cAMP
• interacts with the second PDZ domain of human PTP1e

Compartment

• cytoplasm
• upon binding to M-Ras, translocates to plasma membrane

Alternative splicing

named isoforms=3

Expression

• expressed in brain, heart, liver, lung, placenta > skeletal muscle, kidney, pancreas (isoform 3)

More general terms

• guanine nucleotide exchange factor
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8TEU7.html