Ras-specific guanine nucleotide-releasing factor RalGPS1 (RalA exchange factor RalGPS1, Ral GEF with PH domain & SH3-binding motif 1, RALGPS1, KIAA0351, RALGEF2)

Function

• may be involved in cytoskeletal organization
• may also be involved in the stimulation of transcription (Ras-independent)
• guanine nucleotide exchange factor for small GTPase RALA
• interacts with the SH3 domains of GRB2, NCK1, PLCG1 & SRC
• interacts with RALA

Structure

• contains 1 PH domain
  • mediates binding to membranes (probable)
  • required for guanine nucleotide exchange of RALA
• contains 1 Ras-GEF domain

Compartment

• cytoplasm (putative), cell membrane (probable)
• associates with membranes through the PH domain (probable) Alternative
• splicing, named isoforms=6

Expression

• isoform 2 is expressed in brain, colon, kidney, pancreas, prostate, skeletal muscle, small intestine, testis, thymus & uterus
• isoform 1 is expressed in heart & testis > brain, pancreas, skeletal muscle, small intestine & thymus

More general terms

• guanine nucleotide exchange factor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9649
• UniProt: http://www.uniprot.org/uniprot/Q5JS13.html