FERM, RhoGEF and pleckstrin domain-containing protein 1 (chondrocyte-derived ezrin-like protein, FARP1, CDEP)

Function

• Rho-guanine nucleotide exchange factor (putative)

Structure

• contains 1 DH domain (DBL-homology domain)
• contains 1 FERM domain
• contains 2 PH domains

Alternative splicing

named isoforms=2

Expression

• detected in cAMP-treated chondrocytes, but not in untreated chondrocytes
• detected in fetal brain, heart & spleen, & in adult testis, kidney & lung
• up-regulated in response to cAMP in cultured embryonic chondrocytes

More general terms

• guanine nucleotide exchange factor

Database

• OMIM: https://mirror.omim.org/entry/602654
• UniProt: http://www.uniprot.org/uniprot/Q9Y4F1.html