SH2 domain-containing protein 3C (Novel SH2-containing protein 3, SH2D3C, NSP3, UNQ272/PRO34088/PRO309)

Function

• Eph receptor-binding protein
• positive regulator of TCR signaling (putative)
• binding to BCAR1 is required to induce membrane ruffling & promote EGF-dependent cell migration
• interacts with PTK2B
• isoform 2 interacts with BCAR1/CAS & NEDD9/HEF1

Structure

• contains 1 Ras-GEF domain contains 1 SH2 domain

Compartment

• cytoplasm, membrane
• associated with membrane when EGF-stimulated
• ound at ruffling membranes

Alternative splicing

named isoforms=4

Expression

ubiquitously expressed

More general terms

• guanine nucleotide exchange factor
• phosphoprotein
• SH2 domain-containing protein

Database

• OMIM: https://mirror.omim.org/entry/604722
• UniProt: http://www.uniprot.org/uniprot/Q8N5H7.html