ephexin (eph interacting exchange factor)

Function

• ephexin activity related to ephrin A stimulation of Eph A receptors, leading to rho A activation, cdc42 & Rac1 inhibition
• mediates ephrin induced growth cone collapse

Structure

• member of Dbl family of guanine nucleotide exchange factors for rho GTPases

More general terms

• guanine nucleotide exchange factor

More specific terms

• ephexin-1 (Eph-interacting exchange protein, neuronal guanine nucleotide exchange factor, NGEF)

Additional terms

• eph family receptor
• ephrin A or ephrin A ligand