active breakpoint cluster region-related protein (ABR)

Function

• GTPase-activating protein for RAC & CDC42
• promotes exchange of RAC or CDC42-bound GDP by GTP thus activating them

Structure

• contains 1 C2 domain
• contains 1 DH domain (DBL-homology)
• contains 1 PH domain
• contains 1 Rho-GAP domain

Alternative splicing

named isoforms=2

Expression

expressed in brain >> heart, lung, muscle

More general terms

• guanine nucleotide exchange factor

Database

• OMIM: https://mirror.omim.org/entry/600365
• UniProt: http://www.uniprot.org/uniprot/Q12979.html