septin-6 (SEPT6, KIAA0128, SEP2)

Function

• filament-forming cytoskeletal GTPase. required for normal organization of the actin cytoskeleton
• involved in cytokinesis
• may play a role in HCV RNA replication
• phosphorylated upon DNA damage, probably by ATM or ATR
• septins polymerize into heterooligomeric protein complexes that form filaments, & associate with cellular membranes, actin filaments & microtubules
• GTPase activity is required for filament formation
• filaments are assembled from asymmetrical heterotrimers, composed of SEPT2, SEPT6 & SEPT7 that associate head-to-head to form a hexameric unit
• within the trimer, directly interacts with SEPT2 & SEPT7
• also interacts with SEPT9 & SEPT12
• interaction with SEPT12 alters filament structure
• interacts with SOCS7
• interacts with HCV NS5B & with HNRNPA1

Structure

belongs to the septin family

Compartment

• cytoplasm, cytoskeleton
• spindle, chromosome, centromere, kinetochore, cleavage furrow, midbody
• in metaphase cells, localized within the microtubule spindle
• at the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes
• in cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, & the central spindle

Alternative splicing

named isoforms=4

Expression

• widely expressed
• coordinated expression with SEPT2 & SEPT7

More general terms

• septin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23157
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23157
• OMIM: https://mirror.omim.org/entry/300683
• UniProt: http://www.uniprot.org/uniprot/Q14141.html