septin-2; neural cell expressed developmentally down-regulated protein 5; NEDD-5 (SEPT2, DIFF6, KIAA0158, NEDD5)

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Function

filament-forming cytoskeletal GTPase
required for normal organization of the actin cytoskeleton
role in biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, & by impeding MAP4 binding to tubulin
required for progression through mitosis
forms a scaffold at the midplane of the mitotic splindle
required to maintain CENPE localization at kinetochores & consequently chromosome congression
during anaphase, may be required for chromosome segregation & spindle elongation
may play a role in the internalization of intracellular microbial pathogens, including Listeria monocytogenes & Shigella flexneri
septins polymerize into heterooligomeric protein complexes that form filaments, & associate with cellular membranes, actin filaments & microtubules
GTPase activity is required for filament formation
ilaments are assembled from asymmetrical heterotrimers, composed of SEPT2, SEPT6 & SEPT7 that associate head-to-head to form a hexameric unit
interaction between SEPT2 & SEPT7 seems indirect
interacts with SEPT5
interaction with SEPT4 not detected (putative)
interacts with SEPT9
interacts with MAP4

belongs to the septin family

cytoplasm, cytoskeleton
spindle, chromosome, centromere, kinetochore
cleavage furrow, midbody
in metaphase cells, localized within the microtubule spindle
at the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes
in cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, & the central spindle
during bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria
in epithelial cells, colocalizes with polyglutamylated tubulin around the trans-Golgi network, as well as juxatnuclear & proximal Golgi apparatus