septin-5; cell division control-related protein 1; CDCrel-1; Peanut-like protein 1 (SEPT5 PNUTL1)

Function

• filament-forming cytoskeletal GTPase (putative)
• may play a role in cytokinesis (putative)
• may play a role in platelet secretion (putative)
• in platelets, phosphorylated in response to thrombin, phorbol-12-myristate-13-acetate & collagen
• septins polymerize into heterooligomeric protein complexes that form filaments, & can associate with cellular membranes, actin filaments & microtubules
• GTPase activity is required for filament formation (putative)
• interacts with SEPT2 & SEPT5
• in platelets, associated with a complex containing STX4
• interacts with PARK2
• this interaction leads to SEPT5 ubiquitination & degradation (putative)

Structure

• belongs to the septin family

Compartment

• cytoplasm, cytoskeleton (putative)
• in platelets, found in areas surrounding alpha-granules

Expression

• expressed at high levels in the CNS
• expressed in heart & platelets (at protein level)

Pathology

• deficiency in SEPT5 degradation may contribute to early onset parkinson disease 2 (PARK2)
  • SEPT5 overexpression exerts dopamine-dependent neurotoxicity
  • wild-type PARK2 (but not familial-linked PARK2 mutants) ubiquinates mouse SEPT5 & promotes its degradation

More general terms

• septin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5413
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5413
• OMIM: https://mirror.omim.org/entry/602724
• UniProt: http://www.uniprot.org/uniprot/Q99719.html