syntaxin-4; renal carcinoma antigen NY-REN-31 (STX4, STX4A)

Function

• plasma membrane t-SNARE that mediates docking of transport vesicles
• necessary for translocation of SLC2A4 from intracellular vesicles to plasma membrane (putative)
• role in docking of synaptic vesicles at presynaptic active zones (putative)
• binds STXBP3 & STXBP6
• binding to STXBP3 excludes binding with SNAP25
• interacts with SNAP23 & SNAP25BP
• found in a complex with VAMP8 & SNAP23 in pancreas (putative)
• interacts with VAMP2 & STXBP4 (putative)
• detected in a complex with SNAP23 & STXBP4
• interaction with STXBP4 excludes interaction with VAMP2 (putative)
• interacts with STX4A

Structure

• belongs to the syntaxin family
• contains 1 t-SNARE coiled-coil homology domain

Compartment

membrane

More general terms

• syntaxin

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6810
• OMIM: https://mirror.omim.org/entry/186591
• UniProt: http://www.uniprot.org/uniprot/Q12846.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6810