SNARE-associated protein Snapin; synaptosomal-associated protein 25-binding protein; SNAP-associated protein (SNAPAP, SNAP25BP, SNAPIN)

Function

• component of the BLOC-1 complex
• associates with the SNARE complex
• may modulate a step between vesicle priming, fusion & Ca+2-dependent neurotransmitter release
• potentiates interaction of synaptotagmins with SNAREs & plasma-membrane-associated protein SNAP25
• phosphorylated:
  • phosphorylation state influences exocytotic protein interactions & may regulate synaptic vesicle exocytosis
  • phosphorylation increases its interaction with SNAP25
• SNARE-mediated membrane fusion in non-neuronal cells (putative)
• interacts with SNAP23, SNAP25, STX4A but NOt with STX1A, VAMP2, SYT1
• may anchor to vesicular membrane through an N-terminus

Compartment

• cytoplasm, peripheral membrane, cytoplasmic vesicle

More general terms

• protein subunit
• phosphoprotein

Component of

• biogenesis of lysosome-related organelles complex-1 (BLOC-1 complex)

Database

• OMIM: https://mirror.omim.org/entry/607007
• UniProt: http://www.uniprot.org/uniprot/O95295.html