synaptosomal-associated protein 23; SNAP-23; vesicle-membrane fusion protein SNAP-23 (SNAP23)

Function

• essential component of the high affinity receptor for the general membrane fusion machinery
• regulator of transport vesicle docking & fusion
• binds simultaneously to SNAPIN & SYN4
• found in a complex with VAMP8 & STX4 in pancreas (putative)
• binds tightly to multiple syntaxins & synaptobrevins/VAMPs
• found in a complex with VAMP8 & STX1A

Structure

• belongs to the SNAP-25 family
• contains 2 t-SNARE coiled-coil homology domains

Compartment

• cell membrane, peripheral membrane protein
• cell junction, synapse, synaptosome
• mainly localized to the plasma membrane

Alternative splicing

named isoforms=2; SNAP-23a, SNAP-23b

Expression

• ubiquitous
• highest levels found in placenta

More general terms

• synaptosomal-associated protein (SNAP)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8773
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8773
• OMIM: https://mirror.omim.org/entry/602534
• UniProt: http://www.uniprot.org/uniprot/O00161.html