vesicle-associated membrane protein 8 (VAMP-8, endobrevin, EDB, VAMP8)

Function

• targeting &/or fusion of transport vesicles to their target membrane
• dense-granule secretion in platelets
• regulated enzyme secretion in pancreatic acinar cells
• abscission of the midbody during cell division,
• homotypic fusion of early & late endosomes
• found in a number of SNARE complexes with NAPA, SNAP23, SNAP25, STX1A, STX4, STX7, STX8 & VTI1B
• interacts with STX8

Compartment

membrane

Expression

platelets

More general terms

• SNARE protein

Database

• OMIM: https://mirror.omim.org/entry/603177
• UniProt: http://www.uniprot.org/uniprot/Q9BV40.html