syntaxin-8 (STX8)

Function

• vesicle trafficking protein
• functions in early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the endoplasmic reticulum (ER)
• forms a SNARE complex with STX7, VTI1B & VAMP8 which functions in the homotypic fusion of late endosomes
• part of SNARE core complex containing STX7, VAMP8 & VTI1B
• interacts with VAMP8 (putative)

Structure

• belongs to the syntaxin family
• contains 1 t-SNARE coiled-coil homology domain

Compartment

• membrane
• preferentially associated with early endosome
• to lesser extent, also present in late endosome, plasma membrane & coated pits (putative)

Expression

• expressed in heart > brain, kidney, liver, lung, placenta, skeletal muscle, spleen & pancreas

More general terms

• syntaxin

Component of

• SNARE core complex

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9482
• OMIM: https://mirror.omim.org/entry/604203
• UniProt: http://www.uniprot.org/uniprot/Q9UNK0.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9482