gamma-1-syntrophin; G1SYN; syntrophin-4; SYN4 (SNTG1)

Function

• adapter protein
• binds to & probably organizes subcellular localization of a variety of proteins
• may link various receptors to the actin cytoskeleton & the dystrophin glycoprotein complex (putative)
• may participate in regulating the subcellular location of diacylglycerol kinase-zeta to ensure that diacylglycerol is rapidly inactivated following receptor activation
• isoform 1, but not isoform 2, interacts with the dystrophin protein DMD & related proteins DTNA & DTNB
• interacts with DGKZ

Structure

• the PDZ domain binds to the last 3 or fo4 amino acids of DGKZ
• association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane
• belongs to the syntrophin family
• contains 1 PDZ domain (DHR domain)
• contains 1 PH domain

Compartment

• cytoplasm, cytoskeleton
• nucleus
• mainly cytoplasmic & weakly nuclear
• in CNS, it is expressed in the perikaryon & proximal portion of neuronal processes

Alternative splicing

named isoforms=2

Expression

• brain specific
• strong expression in the hippocampus, neuron-rich dendate granule cells, & pyramidal cell layers
• highly expressed in neurons of the cerebral cortex
• also expressed in the cerebellar cortex, deep cerebellar nuclei, thalamus, & basal ganglia
• no expression in muscle cells

More general terms

• syntrophin (dystrophin-associated protein)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54212
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:54212
• OMIM: https://mirror.omim.org/entry/608714
• UniProt: http://www.uniprot.org/uniprot/Q9NSN8.html