diacylglycerol kinase zeta; DAG kinase zeta; diglyceride kinase zeta; DGK-zeta (DGKZ, DAGK6)

Function

• strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among long chain diacylglycerols
• isoform 2 but not isoform 1 regulates RASGRP1 activity
• phosphorylation of the MARCKS homology domain by PKC reduces nuclear accumulation of DGK-zeta
• interacts with the PDZ domain of the syntrophin SNTG1 & that of SNX27
• isoform 2 forms a signaling complex with RASGRP1 & HRAS

ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate

Structure

• belongs to the eukaryotic diacylglycerol kinase family
• contains 2 ANK repeats
• contains 1 DAGKc domain
• contains 2 phorbol-ester/DAG-type Zn+2 fingers

Compartment

cytoplasm, nucleus, cell membrane

Alternative splicing

named isoforms=2

Expression

• highest levels in brain
• high levels in skeletal muscle, heart, & pancreas
• isoform 1 is predominantly expressed in muscle

More general terms

• diacylglycerol kinase
• ankyrin repeat domain protein (ANKRD)
• zinc finger protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8525
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8525
• OMIM: https://mirror.omim.org/entry/601441
• UniProt: http://www.uniprot.org/uniprot/Q13574.html