Mmyristoylated alanine-rich C-kinase substrate; MARCKS; protein kinase C substrate, 80 kD protein, light chain; PKCSL; 80K-L protein (MARCKS, MACS, PRKCSL)

Function

• filamentous F-actin cross-linking protein
• phosphorylation by protein kinase C
  • displaces MARCKS from plasma membrane
  • inhibits the F-actin cross-linking activity
• binds calmodulin, actin, & synapsin

Structure

belongs to the MARCKS family

Compartment

• cytoplasm, cytoskeleton (probable)
• membrane; lipid-anchor (putative)
• localizes to focal adhesion contact sites

More general terms

• myristoylated protein
• phosphoprotein
• calmodulin binding protein

Additional terms

• MARCKS-related protein; MARCKS-like protein 1; macrophage myristoylated alanine-rich C kinase substrate; mac-MARCKS; macMARCKS (MARCKSL1 MLP MRP)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4082
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4082
• OMIM: https://mirror.omim.org/entry/177061
• UniProt: http://www.uniprot.org/uniprot/P29966.html