synaptotagmin

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Introduction

Synaptotagmins 1-5. Possibly couples secretion to neuronal activity. A component of the neuronal secretory machinary without a yeast counterpart. Binds acidic phospholipids with a specificity that requires both an acidic headgroup & a diacyl backbone. Also facilitates actin-dependent filopodial extension of neurites[4]. Syntaxins associate with synaptotagmin.

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References

  1. Perin MS, Brose N, Jahn R, Sudhof TC. Domain structure of synaptotagmin (p65) J Biol Chem. 1991 Jan 5;266(1):623-9. Erratum in: J Biol Chem 1991 May 25;266(15):10018. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1985919
  2. Allbritton NL, Meyer T, Stryer L. Range of messenger action of calcium ion and inositol 1,4,5-trisphosphate. Science. 1992 Dec 11;258(5089):1812-5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1465619
  3. UniProt http://www.uniprot.org/uniprot/P21579.html
  4. 4.0 4.1 Feany MB, Buckley KM. The synaptic vesicle protein synaptotagmin promotes formation of filopodia in fibroblasts. Nature. 1993 Aug 5;364(6437):537-40. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8166886
    Kelly RB. Secretion. A question of endosomes. Nature. 1993 Aug 5;364(6437):487-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8336787
  5. Bennett MK, Miller KG, Scheller RH. Casein kinase II phosphorylates the synaptic vesicle protein p65. J Neurosci. 1993 Apr;13(4):1701-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8463845