synaptotagmin-3; synaptotagmin III; SytIII (SYT3)

Function

• may be involved in Ca+2-dependent exocytosis of secretory vesicles through Ca+2 & phospholipid binding to the C2 domain or may serve as Ca+2 sensors in the process of vesicular trafficking & exocytosis (putative)

Cofactor: binds 3 Ca+2 per subunit via the C2 domains (putative)

Structure

• homodimer. can also form heterodimers (putative)
• the first C2 domain mediates Ca+2-dependent phospholipid
• binding
• belongs to the synaptotagmin family
• contains 2 C2 domains

Compartment

• cytoplasmic vesicle, secretory vesicle
• synaptic vesicle membrane

More general terms

• synaptotagmin

Database

• OMIM: https://mirror.omim.org/entry/600327
• UniProt: http://www.uniprot.org/uniprot/Q9BQG1.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84258
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:84258