synaptotagmin-7; synaptotagmin VII; SytVII; prostate cancer-associated protein 7; IPCA-7 (SYT7, PCANAP7)

Function

• may be involved in Ca+2-dependent exocytosis of secretory vesicles through Ca+2 & phospholipid binding to the C2 domain or may serve as Ca+2 sensors in the process of vesicular trafficking & exocytosis (putative)
• interacts with SYNCRIP isoform 3 C-terminus

Cofactor: binds 3 Ca+2 per subunit via the C2 domains (putative)

Structure

• the second C2 domain/C2B is responsible for SYNCRIP binding (putative)
• belongs to the synaptotagmin family
• contains 2 C2 domains

Compartment

• cytoplasmic vesicle, secretory vesicle
• synaptic vesicle membrane

Expression

expressed in a variety of adult & fetal tissues

More general terms

• synaptotagmin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9066
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9066
• OMIM: https://mirror.omim.org/entry/604146
• UniProt: http://www.uniprot.org/uniprot/O43581.html