synaptotagmin-2; synaptotagmin II; SytII (SYT2)

Function

• may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse
• binds acidic phospholipids with a specificity that requires the presence of both an acidic head group & a diacyl backbone (putative)
• interacts with stonin 2
• interacts with SCAMP5

Cofactor: binds 3 Ca+2 per subunit via the C2 domains (putative)

Structure

• homotetramer (probable).
• the first C2 domain mediates Ca+2-dependent phospholipid binding (putative)
• the second C2 domain mediates interaction with stonin 2
• belongs to the synaptotagmin family
• contains 2 C2 domains

Compartment

• cytoplasmic vesicle, secretory vesicle
• synaptic vesicle membrane
• cytoplasmic vesicle, secretory vesicle
• chromaffin granule membrane
• synaptic vesicles & chromaffin granules (putative)

More general terms

• synaptotagmin

Database

• OMIM: https://mirror.omim.org/entry/600104
• UniProt: http://www.uniprot.org/uniprot/Q8N9I0.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:127833
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=127833