stonin-2 (stoned B, STON2, STN2, STNB)

Function

• adapter protein involved in endocytosis
• role in vesicle recycling
• facilitates clathrin-coated vesicle uncoating (putative)
• interacts with the second C2 domain of synaptotagmins SYT1 & SYT2
• interacts with EPS15, EPS15R & ITSN1
• interacts indirectly with AP-2 adapter complex
• Asn-Pro-Phe (NPF) motifs mediate the interaction with EH domain of SYT1, SYT2, EPS15, EPS15R & ITSN1

Structure

• belongs to the Stoned B family
• contains 1 MHD domain (mu homology domain) contains 1 SHD domain (stonin homology domain)

Compartment

cytoplasm, some fraction is membrane-associated

Alternative splicing

named isoforms=2

Expression

ubiquitous

More general terms

• other protein

Database

• OMIM: https://mirror.omim.org/entry/608467
• UniProt: http://www.uniprot.org/uniprot/Q8WXE9.html