epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein, Eps15R, EPS15L1, EPS15R)

Function

• constitutive component of clathrin-coated pits
• required for receptor-mediated endocytosis
• interacts with EPS15, HRB & HRBL
• associates with clathrin-associated adapter protein complex 2 (AP-2)
• phosphorylated on Tyr by EGFR

Structure

• contains 1 EF-hand domain
• contains 3 EH domains

Compartment

• cell membrane, nucleus
• localized to plasma membrane coated pits

More general terms

• phosphoprotein
• membrane protein
• Ca+2 binding protein

Component of

• clathrin-coated pit

Database

• UniProt: http://www.uniprot.org/uniprot/Q9UBC2.html