Arf-GAP domain & FG repeat-containing protein 1; HIV-1 Rev-binding protein; nucleoporin-like protein RIP; Rev-interacting protein; Rev/Rex activation domain-binding protein (AGFG1, HRB, RAB, RIP)

Function

• required for vesicle docking or fusion during acrosome biogenesis (putative)
• may play a role in RNA trafficking or localization
• interacts with EPS15R & EPS15
• interacts with FCHO1

Structure

• O-glycosylated (putative)
• contains FG repeats
  • the FG repeat region is required for HIV-1 Rev protein interaction
• contains 1 Arf-GAP domain

Compartment

• nucleus
• cytoplasmic vesicle

Alternative splicing

named isoforms=3

Expression

ubiquitously expressed

Pathology

• interacts specifically with the HIV-1 Rev protein effector domain & promotes RNA export
• promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm (essential for HIV-1 replication)

More general terms

• zinc finger protein
• nuclear protein
• glycoprotein
• phosphoprotein

Additional terms

• HIV-1 Rev-binding protein 2; Rev-interacting protein 1; Rip-1 (HRB2, KRR1)
• nucleoporin (nuclear pore complex protein)
• receptor-interacting serine/threonine protein kinase 1; serine/threonine protein kinase RIP; cell death protein RIP; receptor-interacting protein (RIPK1, RIP)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3267
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3267
• OMIM: https://mirror.omim.org/entry/600862
• UniProt: http://www.uniprot.org/uniprot/P52594.html