epidermal growth factor receptor substrate 15 (EGFR substrate 15, protein Eps15, AF-1p protein. EPS15, AF1P)

Function

• cell growth regulation
• regulation of mitogenic signals & control of cell proliferation
• internalization of ligand-inducible tyrosine kinase receptors, including EGFR
• binds AP2A2, STN2, EPN1
• interacts with CRK via its SH3-binding sites
• phosphorylation on Tyr-849
  • role in the internalization of EGFR
• forms heterotrimer with HGS, & either STAM1 or STAM2

Structure

• contains 2 EF-hand domains
• contains 3 EH domains
• contains 2 UIM repeats (ubiquitin-interacting motif)

Compartment

• cytoplasm, cell membrane
• recruited to the plasma membrane upon EGFR activation & localizes to coated pits

Expression

ubiquitously expressed

Pathology

• chromosomal translocation t(1;11)(p32;q23) with MLL/HRX is found in acute leukemia

More general terms

• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/600051
• UniProt: http://www.uniprot.org/uniprot/P42566.html