signal transducing adapter molecule 1 (STAM1)

Function

• role in intracellular signal transduction mediated by cytokines & growth factors
• upon IL-2 & GM-CSL stimulation, iit plays a role in signaling leading to DNA synthesis & MYC induction
• may also play a role in T-cell development
• role in down-regulation of receptor tyrosine kinase via multivesicular body when complexed with HGS (ESCRT-0 complex)
• phosphorylated on Tyr-198
  • phosphorylated in response to IL2, IL3, IL4, IL7, CSF2/GM-CSF, EGF & PDGFB
  • phosphorylated by activated PDGFRB
• component of the ESCRT-0 complex
• probably part of a complex at least composed of HSG, STAM & EPS15 (variant of ESCRT-0 complex)
• interacts with STAMBP/AMSH
• interacts with PDGFRB

Structure

• belongs to the STAM family
• contains 1 ITAM domain
• contains 1 SH3 domain
• contains 1 UIM (ubiquitin-interacting motif) repeat
• contains 1 VHS domain

Compartment

• cytoplasm (probable)
• early endosome membrane
• peripheral membrane, cytoplasmic side (probable)

Alternative splicing

named isoforms=2

Expression

ubiquitously expressed

More general terms

• phosphoprotein

Component of

• ESCRT-0 complex; STAM1/STAM2-HGS complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8027
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8027
• OMIM: https://mirror.omim.org/entry/601899
• UniProt: http://www.uniprot.org/uniprot/Q92783.html