STAM-binding protein (associated molecule with the SH3 domain of STAM, STAMBP, AMSH)

Function

• deubiquitinating enzyme, ubiquitin-protein or polyubiquitin hydrolase (putative)
• functions at the endosome, apposes ubiquitin-dependent sorting of receptors to lysosomes
• role in signal transduction for cell growth & MYC induction mediated by IL-2 & GM-CSF
• potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 & SMAD7
• inhibited by N-ethylmaleimide
• interacts with STAM1, SMAD6, SMAD7
• phosphorylated after BMP type 1 receptor activation

ubiquitin C-terminal thioester + H2O <--> ubiquitin + thiol

Structure

• binds 1 Zn+2 per subunit
• belongs to the peptidase M67C family
• contains 1 MPN domain (JAB/Mov34 domain)

Compartment

nucleus, peripheral membrane, cytoplasm

Expression

ubiquitously expressed

More general terms

• metalloprotease
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/606247
• UniProt: http://www.uniprot.org/uniprot/O95630.html