synaptotagmin-4; synaptotagmin IV; SytIV (SYT4 KIAA1342)

Function

• may be involved in Ca+2-dependent exocytosis of secretory vesicles through Ca+2 & phospholipid binding to the C2 domain or may serve as Ca+2 sensors in the process of vesicular trafficking & exocytosis

Cofactor: binds 3 Ca+2 per subunit via the C2 domains (putative)

Structure

• belongs to the synaptotagmin family
• contains 2 C2 domains

Compartment

• cytoplasmic vesicle, secretory vesicle
• synaptic vesicle membrane

Expression

• expressed in brain
• within brain, expression is highest in hippocampus, with substantial levels also detected in amygdala & thalamus

More general terms

• synaptotagmin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6860
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6860
• OMIM: https://mirror.omim.org/entry/600103
• UniProt: http://www.uniprot.org/uniprot/Q9H2B2.html