synaptotagmin-5; synaptotagmin V; SytV (SYT5)

Function

• may be involved in Ca+2-dependent exocytosis of secretory vesicles through Ca+2 & phospholipid binding to the C2 domain or may serve as Ca+2 sensors in the process of vesicular trafficking & exocytosis
• regulates the Ca+2-dependent secretion of norepinephrine in PC12 cells
• required for export from the endocytic recycling compartment to the cell surface (putative)

Cofactor: binds 3 Ca+2 per subunit via the C2 domains (putative)

Structure

• homodimer
• can also form heterodimers
• interacts with both alpha-tubulin & beta-tubulin (putative)
• belongs to the synaptotagmin family
• contains 2 C2 domains

Compartment

• cytoplasmic vesicle, secretory vesicle
• synaptic vesicle membrane
• recycling endosome membrane
• in mast cells, localizes to endocytic recycling compartment (putative)

More general terms

• synaptotagmin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6861
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6861
• OMIM: https://mirror.omim.org/entry/600782
• UniProt: http://www.uniprot.org/uniprot/O00445.html