Rab effector MyRIP; exophilin-8; myosin-VIIa- & Rab-interacting protein; synaptotagmin-like protein lacking C2 domains C; SlaC2-c; Slp homolog lacking C2 domains c (MYRIP, SLAC2C)
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Function
- Rab effector protein involved in melanosome transport
- serves as link between melanosome-bound RAB27A & the motor proteins MYO5A & MYO7A
- may link RAB27A-containing vesicles to actin filaments
- functions as a protein kinase A-anchoring protein
- may act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (putative)
- binds MYO5A, MYO7A & F-actin (putative)
- binds RAB27A that has been activated by GTP-binding via its N-terminus
- interacts with PRKAR2A
- interacts with components of the exocyst complex, including EXOC3 & EXOC4 (putative)
Structure
- contains 1 FYVE-type Zn+2 finger
- contains 1 RabBD (Rab-binding) domain
Compartment
- cytoplasm (putative), perinuclear region (putative)
- cytoplasmic vesicle, secretory vesicle (putative)
- in presynpatic & postsynaptic areas in photoreceptor cells & in the basal microvilli of retinal pigment epithelial cells
- associated with melanosomes
- colocalizes with actin filaments (putative)
Alternative splicing
named isoforms=5
Expression
- detected in brain, skin, heart, adrenal medulla, pancreas, intestine, liver, kidney, muscle & testis