synaptotagmin-11; synaptotagmin XI; SytXI (SYT11 KIAA0080)

Function

• may be involved in Ca+2-dependent exocytosis of secretory vesicles through Ca+2 & phospholipid binding to the C2 domain or may serve as Ca+2 sensors in the process of vesicular trafficking & exocytosis (putative)
• ubiquitinated & targeted to the proteasome complex for degradation
• interacts with PARK2

Cofactor: binds 3 Ca+2 per subunit via the C2 domains (putative)

Structure

• homodimer
• can also form heterodimers (putative)
• belongs to the synaptotagmin family
• contains 2 C2 domains

Compartment

• membrane, cell junction, synapse (putative)
• cytoplasmic vesicle, secretory vesicle
• synaptic vesicle membrane
• in substantia nigra, observed in neuronal cell bodies & neurites

Pathology

• found in the core of the Lewy bodies in the brain of sporadic parkinson disease patients

More general terms

• synaptotagmin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23208
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23208
• OMIM: https://mirror.omim.org/entry/608741
• UniProt: http://www.uniprot.org/uniprot/Q9BT88.html