syntaxin-binding protein 6; amisyn (STXBP6, HSPC156)

Function

• forms non-fusogenic complexes with SNAP25 & STX1A, thus may modulate formation of functional SNARE complexes & exocytosis
• part of a ternary complex containing SNAP25 & STX1A that can be dissociated by NAPA & NSF
• interacts with STX4A

Structure

-contains 1 v-SNARE coiled-coil homology domain

Compartment

• cytoplasm. membrane; peripheral membrane protein

Alternative splicing

• named isoforms=3
• may be due to an intron retention

Expression

• detected at low levels in brain, & at very low levels in heart, adrenal gland, testis, liver & kidney

More general terms

• UNC-18 homolog or syntaxin binding protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=29091
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:29091
• OMIM: https://mirror.omim.org/entry/607958
• UniProt: http://www.uniprot.org/uniprot/Q8NFX7.html