septin-4; bradeion beta; brain protein H5; CE5B3 beta; cell division control-related protein 2; hCDCREL-2; cerebral protein 7; peanut-like protein 2; apoptosis-related protein in the TGF-beta signaling pathway (SEPT4, PNUTL2, SEP4, hucep-7)

Function

• filament-forming cytoskeletal GTPase (putative)
• may play a role in cytokinesis (putative)
• may play a role in platelet secretion
• isoform 6, but not the other isoforms, is required for induction of cell death mediated by TGF-beta & by other apoptotic stimuli
• septins polymerize into heterooligomeric protein complexes that form filaments, & can associate with cellular membranes, actin filaments & microtubules
• GTPase activity is required for filament formation (putative)
• interacts with SEPT8
• in a mesenchymal cell line, interacts with SEPT9 isoform 2

Structure

belongs to the septin family

Compartment

• cytoplasm (putative)
• cytoskeleton (putative)
• in platelets, found in areas surrounding alpha-granules
• isoform 6:
  • mitochondrion, nucleus
  • predominantly localized in the mitochondria under resting conditions
  • translocates into the nucleus after TGF-beta treatment & induction of apoptosis

Alternative splicing

named isoforms=6

Expression

• widely expressed in adult & fetal tissues
• highest expression in adult brain (at protein level), heart, liver & adrenal gland & fetal heart, kidney, liver & lung
• also expressed in colorectal cancers & malignant melanomas
• expressed in platelets

More general terms

• septin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5414
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5414
• OMIM: https://mirror.omim.org/entry/603696
• UniProt: http://www.uniprot.org/uniprot/O43236.html