septin-8 (SEPT8 KIAA0202)

Function

• filament-forming cytoskeletal GTPase (putative)
• may play a role in cytokinesis
• may play a role in platelet secretion
• septins polymerize into heterooligomeric protein complexes that form filaments, & can associate with cellular membranes, actin filaments & microtubules
• GTPase activity is required for filament formation (putative)
• interacts with CDK14, SEPT4, SEPT5 & SEPT7 (putative)

Structure

belongs to the septin family

Compartment

• cytoplasm, cytoskeleton (putative)
• in platelets, found in areas surrounding alpha-granules

Alternative splicing

• named isoforms=3
• KIAA0202a differs from KIAA0202c at the level of the 3'-UTR

Expression

• widely expressed, including in brain, heart & platelets
• most abundant in aorta
• isoform 2 is expressed at low levels in brain regions, including occipital pole, frontal lobe, temporal lobe & putamen
• isoform 1 & 3 are highly expressed in specific brain areas, including occipital pole, frontal lobe, temporal lobe & putamen
• isoform 2 is highly expressed in prostate, testis & ovary
• isoform 1 & isoform 3 are expressed at low levels in prostate, testis & ovary

More general terms

• septin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23176
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23176
• OMIM: https://mirror.omim.org/entry/608418
• UniProt: http://www.uniprot.org/uniprot/Q92599.html