cyclin-dependent kinase-14 (CDK14); cell division protein kinase 14; serine/threonine protein kinase PFTAIRE-1; hPFTAIRE1 (CDK14, KIAA0834, PFTK1)

Function

• serine/threonine protein kinase
• role in control of the eukaryotic cell cycle
• cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at Ser-1490, leading to activation of the Wnt signaling
• regulator of cell cycle progression & cell proliferation via its interaction with CCDN3
• phosphorylates RB1 in vitro
• may also play a role in meiosis, neuron differentiation & may indirectly act as a negative regulator of insulin-responsive glucose transport
• serine/threonine protein kinase activity is enhanced by associated cyclins CCDN3 & CCNY & repressed by CDKN1A
• interacts with CCNY
  • CCNY mediates its recruitment to the plasma membrane & promotes phosphorylation of LRP6
• interacts with CCDN3 & CDKN1A
• interacts with SEPT8
• interacts with 14-3-3 proteins YWHAB, YWHAE, YWHAH & YWHAQ

Structure

• belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
• contains 1 protein kinase domain

Compartment

• cell membrane; cytoplasm, nucleus
• recruited to the cell membrane by CCNY

Alternative splicing

named isoforms=3

Expression

• highly expressed in brain, pancreas, kidney, heart, testis & ovary
• detected at lower levels in other tissues
• barely detected in spleen & thymus

More general terms

• cyclin-dependent kinase (CDK)
• human longevity protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5218
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5218
• OMIM: https://mirror.omim.org/entry/610679
• UniProt: http://www.uniprot.org/uniprot/O94921.html