microtubule-associated protein 4; MAP-4 (MAP4)

Function

• non-neuronal microtubule-associated protein
• promotes microtubule assembly
• phosphorylated upon DNA damage, probably by ATM or ATR
• phosphorylation on Ser-787 negatively regulates MAP4
• activity to promote microtubule assembly
• isoform 3 is phosphorylated on Ser-337 & Ser-338

Structure

contains 4 Tau/MAP repeats

Alternative splicing

named isoforms=6

Expression

• non neuronal cells, although some neurons express MAP4

More general terms

• microtubule-associated protein (MAP)

Database

• UniProt: http://www.uniprot.org/uniprot/P27816.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4134
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4134
• OMIM: https://mirror.omim.org/entry/157132