protein phosphatase 1 regulatory subunit 12B; myosin phosphatase-targeting subunit 2; myosin phosphatase target subunit 2 (PPP1R12B, MYPT2)

Function

• regulates myosin phosphatase activity
• augments Ca+2 sensitivity of the contractile apparatus
• isoform 3 & isoform 4 bind PPP1R12A, but not isoform 1 of PPP1R12B itself
• binds IL16

Structure

contains 5 ANK repeats

Compartment

• cytoplasm
• along actomyosin filaments & stress fibers

Alternative splicing

• named isoforms=4
• alternative promoter usage

Expression

• detected in skeletal muscle, fetal & adult heart, brain, placenta, kidney, spleen, thymus, pancreas & lung
• isoform 3 & isoform 4 are heart specific

More general terms

• protein phosphatase-1 regulatory subunit
• ankyrin repeat domain protein (ANKRD)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4660
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4660
• OMIM: https://mirror.omim.org/entry/603768
• UniProt: http://www.uniprot.org/uniprot/O60237.html