protein phosphatase-1 regulatory subunit 3C (protein phosphatase 1 regulatory subunit 5, R5, protein targeting to glycogen, PTG, PPP1R3C, PPP1R5)

Function

• glycogen-targeting subunit for PP1 & regulates its activity
• activates glycogen synthase
• diminishes glycogen phosphorylase activity
• limits glycogen breakdown
• increases basal & insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types
• interacts with PPP1CC catalytic subunit of PP1 & associates with glycogen
• forms complexes with glycogen phosphorylase, glycogen synthase & phosphorylase kinase which is necessary for its regulation of PP1 activity
• interacts with EPM2A/laforin

Structure

• contains 1 CBM21 domain (carbohydrate binding type-21)
• N-terminal region is required for binding to PP1
• central region is required for binding to glycogen
• C-terminal region is required for binding to glycogen phosphorylase, glycogen synthase & phosphorylase kinase

More general terms

• protein phosphatase-1 regulatory subunit

Database

• OMIM: https://mirror.omim.org/entry/602999
• UniProt: http://www.uniprot.org/uniprot/Q9UQK1.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=89799
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5507