aspirin/oxycodone (Percodan)

Introduction

5 mg oxycodone + 325 mg aspirin: DEA-controlled substance: class 2.

Contraindications

pregnancy-category D

safety in lactation -

Dosage

1 tabs PO every 6 hours

Tablets: oxycodone HCl 4.5 mg, oxycodone terephthalate 0.38 mg & aspirin 325 mg

Pharmacokinetics

elimination: liver > kidney

Adverse effects

• common (> 10%)
  • weakness, tiredness, nausea/vomiting, hypotension, drowsiness, dizziness, heartburn, epigastric pain, dyspepsia
• less common (1-10%)
  • ureteral spasms, pain at site of injection, nervousness, headache, restlessness, anorexia, malaise, epigastric cramps, dry mouth, constipation, biliary spasm, decreased urination, confusion, dyspnea*, hemolytic anemia, rash, gastrointestinal ulceration, anaphylactic shock
• uncommon (< 1%)
  • paralytic ileus, depression, histamine release, hallucinations, paradoxical CNS stimulation, urticaria, increased intracranial pressure, physical & psychologic dependence, insomnia, nervousness, jitters, occult bleeding, prolongation of bleeding time, leukopenia, thrombocytopenia, hepatotoxicity, bronchospasm, iron deficiency anemia, renal insufficiency

* respiratory depression is dose & tolerance-related

• drug adverse effects of opiates
• drug adverse effects of psychotropic agents
• drug adverse effects of sedatives

More general terms

• narcotic combination

Components

• aspirin (Ecotrin, Empirin, Bayer aspirin, Vazalore, ASA)
• oxycodone (Roxicodone, OxyContin, OxyIR, OxyFast, Oxecta, Xtampza ER)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=656791