histamine

Biochemistry

(also see histamine receptor)

mediator of allergic reactions

mediator of gastric acid secretion

neurotransmitter

Pharmacology

histamine phosphate, histamine diphosphate

Indications

• diagnostic testing for achlorhydria
• diagnostic testing for pheochromocytoma
• symptomatic relief from dizziness/vertigo
• antigen desensitization

Contraindications

• severe hypertension
• hypotension
• bronchial asthma
• vasomotor instability
• urticaria
• severe cardiac, pulmonary or renal disease

Dosage

• gastric function testing:
  • 0.0275 mg/kg histamine phosphate (10 ug/kg histamine) SC
• pheochromocytoma
  • 0.0275 mg/kg histamine phosphate (10 ug/kg histamine) IV
  • if no response with 5 minutes, 0.1375 mg/kg histamine phosphate (50 ug/kg histamine) IV
• monitor blood pressure frequently during & immediately following administration
• dizziness: 3 drops under tongue prn

Injection:

• 0.55 mg (equivalent to 0.2 mg histamine base)/mL (5 mL)
• 2.75 mg (equivalent to 1.0 mg histamine base)/mL (1 mL)

More general terms

• amine
• imidazole; glyoxaline; 1,3-diazole; iminazole
• bioagent

Additional terms

• histamine receptor

Component of

• histamine/menthol/methyl salicylate
• activon/histamine/menthol
• histamine/menthol

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=774
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=65513
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5818